Table 1.

Early protective immunity is operative in L. monocytogenes infection and is nonspecifica

Priming dose Challenge doseNo. of deaths/total no. of miceMTD (days)
PBS2.5 × 105EGD4/54.0 ± 1.7
105 EGD2.5 × 105 EGD0/5
105 EGD2.5 × 106EGD1/54
105 EGD2.5 × 107 EGD5/53.4 ± 0.5
PBS105LVS5/54.4 ± 0.9
104LVS105 LVS0/5
104 LVS106LVS3/55.0 ± 1.7
104LVS107 LVS5/54.4 ± 0.5
104 LVS2.5 × 105EGD1/54
104 LVS2.5 × 106 EGD2/55.0 ± 1.4
104LVS2.5 × 107 EGD5/52.6 ± 0.5
105 EGD105LVS1/55
105EGD106 LVS2/54.5 ± 2.1
105 EGD107LVS5/54.0 ± 1.2
  • a BALB/cByJ mice (groups of five) were primed i.d. on day 0 and challenged i.p. on day 3 with numbers and strains of bacteria as indicated; actual priming and challenge doses were confirmed by plate count at the time of inoculation. Mice were observed for morbidity and mortality through day 60. The MTD was determined in relationship to the day of i.p. challenge. This experiment is representative of five total experiments of similar design.