Table 1.

Volunteers with significant responses against CFAs and CTB in intestinal lavage fluid, feces, and serum and significant blood ASC responses after two oral doses of ETEC vaccine

Vaccine antigenNo. (%) with significant response/no. testeda
LavageFecesASCSerum
CFA/I20/23 (87)17/21 (81)19/24 (79)14/25 (56)
CS1/316/23 (70)11/21 (52)19/25 (76)5/25 (20)
CS214/23 (61)8/21 (38)15/23 (65)7/25 (28)
CS415/23 (65)9/21 (43)17/25 (68)2/25 (8)
CTB22/23 (96)19/21 (90)25/25 (100)23/25 (92)
  • a Increases of ≥twofold in vaccine-specific IgA antibody titer per total IgA (lavage, feces), in number of specific IgA ASCs, and in specific IgA antibody titer (serum) between pre- and postimmune specimens were considered significant responses in the respective assays.