Table 4.

Comparison of immune responses in serum with those in intestinal lavage after two oral immunizations with the ETEC vaccinea

ParameterValue (%) for vaccine antigen
Positive predictive value938083NCb 100
  • a Samples collected 7 days (serum) and 9 days (lavage) after the second dose from 22 or 23 volunteers were assayed for specific IgA antibodies per total IgA responses in lavage and serum IgA responses to the respective antigens. The percentage of volunteers responding both in serum and lavage in relation to those responding in lavage (sensitivity) and in serum (positive predictive value) is given for each antigen.

  • b NC, not calculated because the numbers in the denominator were too low.