TABLE 4.

Impact of upregulation of minor OMPs on the induction of complement-mediated killing by bactericidal antibodies in mice

porA knockout galE OMV vaccineMenB strain H44/76MenB strain Cu385MenB strain NZ124/98
Geometric mean titer for 50% killinga95% Confidence intervalSeroconversion (%)bGeometric mean titer for 50% killing95% Confidence intervalSeroconversion (%)bGeometric mean titer for 50% killing95% Confidence intervalSeroconversion (%)b
No upregulation7146-109155942-8255050-500
TbpA upregulated13461-2963011757-241308548-14920
Hsf upregulated7445-122157344-121158852-14925
TbpA and Hsf upregulated727342-1,54690244117-5116522291-54245
  • a The geometric mean titer for 50% killing was calculated with individual sera (n = 20)..

  • b Percentage of responder mice (titer, >50).