TABLE 4.

Impact of upregulation of minor OMPs on the induction of complement-mediated killing by bactericidal antibodies in mice

porA knockout galE OMV vaccine	MenB strain H44/76			MenB strain Cu385			MenB strain NZ124/98
porA knockout galE OMV vaccine	Geometric mean titer for 50% killing^a	95% Confidence interval	Seroconversion (%)^b	Geometric mean titer for 50% killing	95% Confidence interval	Seroconversion (%)^b	Geometric mean titer for 50% killing	95% Confidence interval	Seroconversion (%)^b
No upregulation	71	46-109	15	59	42-82	5	50	50-50	0
TbpA upregulated	134	61-296	30	117	57-241	30	85	48-149	20
Hsf upregulated	74	45-122	15	73	44-121	15	88	52-149	25
TbpA and Hsf upregulated	727	342-1,546	90	244	117-511	65	222	91-542	45

↵a The geometric mean titer for 50% killing was calculated with individual sera (n = 20)..
↵b Percentage of responder mice (titer, >50).