Table 1.

Multiplication of E. chaffeensis in infected tissues of immunocompromised mice

Day postinfectionNo. of infected cells per fielda in:
LiverbSpleen
C.B-17-scid miceC.B-17-scid/bgmiceC.B-17-scid miceC.B-17-scid/bg mice
300NDcND
101 ± 10.8 ± 0.83ND ND
173.2 ± 2.44.6 ± 1.77.0 ± 1.34.9 ± 3.1
2411.7 ± 4.32.1 ± 2.1d7.3 ± 1.18.5 ± 4.2
  • a Values are the means and standard deviations of E. chaffeensis-positive cells detected in the tissues of the indicated strains by immunohistochemistry (5 to 10 fields per group; magnification, ×1,000).

  • b Liver sections contained on average 90.5 ± 16.4 hepatocytes/field; spleen sections contained 482 ± 120 cells/field.

  • c ND, not determined.

  • d Substantial necrosis was present in these tissue sections.