TABLE 1

CYS and CTM potentiate the antimicrobial activities of ciprofloxacin and reactive oxygen and nitrogen species; MICs of ciprofloxacin, paraquat, H2O2, and SNAP versus P. aeruginosa PAO1

DrugMIC (μg/ml)
AloneIn combination
CYS vs. ciprofloxacin
    CYS256128
    Ciprofloxacin0.06250.0325
CTM vs. ciprofloxacin
    CTM1,024256
    Ciprofloxacin0.06250.03125
CYS vs. paraquat
    CYS256<16
    Paraquat>154.377.1
CTM vs. paraquat
    CTM1,02464
    Paraquat>154.30.3
CYS vs. H2O2
    CYS256256
    H2O22.4431.22
CTM vs. H2O2
    CTM1,024<32
    H2O22.4430.305
CYS vs. SNAP
    CYS256128
    SNAP>55
CTM vs. SNAP
    CTM1,02464
    SNAP>50.3125