TABLE 3

Stress response- and virulence-related genes that were differentially expressed between the mutants and wild-type Y. pestis

Gene IDGene nameGene productLog2 ratio of fold changes
ΔcobB/WTΔyfiQ/WT
Virulence genes
    YP_1290psaFHypothetical protein−4.34−4.14
    YP_1289psaAAdhesin−2.62−2.07
    YP_1291psaERegulatory protein−3.78−4.15
    YP_1288psaBChaperone protein PsaB−2.10−4.07
    YP_1698hmsSHemin storage system protein−2.14−1.94
    YP_1697hmsRN-Glycosyltransferase−1.82−1.94
    YP_1695hmsHHypothetical protein−1.11−1.81
    YP_1696hmsFOuter membrane N-deacetylase−1.54−2.09
    YP_1764phoPDNA-binding transcriptional regulator PhoP0.871.23
    YP_0141hslRHeat shock protein 15−0.57−1.01
    YP_2160slyAMarR family transcriptional regulatory protein−2.11−2.19
    YP_pPCP08plaOuter membrane protease1.041.43
    YP_0910pla2Outer membrane protease4.003.52
Stress response genes
    YP_2475hdeBAcid resistance protein−1.54−0.99
    YP_0936adiAAmino acid decarboxylase−4.00−3.77
    YP_1228cspDCold shock-like protein1.261.49
    YP_3903cspa1Major cold shock protein Cspa1−0.57−1.23
    YP_1764phoPDNA-binding transcriptional regulator PhoP0.871.23
    YP_0811htpGHeat shock protein 90−1.15−0.84
    YP_0108hslVHeat shock protein−1.05−1.01
    YP_0141hslRHeat shock protein 15−0.57−1.01
    YP_3994ibpAHeat shock protein IbpA−1.14−0.35
    YP_0397lytTTwo-component response-regulatory protein YehT1.001.45
    YP_3333uspA2Universal stress protein A0.891.58