TABLE 1.

Selected P. aeruginosa genes that were dysregulated in the presence of LL-37

IdentificationDesignationChange (n-fold) in regulationP valueProtein
Type IV pili
    PA0395pilT1.60.027Twitching motility protein PilT
    PA0410pilI1.90.015Twitching motility protein PilI
    PA0411pilJ2.10.004Twitching motility protein PilJ
    PA4528pilD1.60.023Type 4 prepilin peptidase PilD
    PA4550fimU2.60.007Type 4 fimbrial biogenesis protein FimU
    PA4551pilV1.80.002Type 4 fimbrial biogenesis protein PilV
    PA4552pilW2.70.003Type 4 fimbrial biogenesis protein PilW
    PA4554pilY12.30.002Type 4 fimbrial biogenesis protein PilX
Flagella
    PA1077flgB−2.80.039Flagellar basal-body rod protein FlgB
    PA1086flgK−2.20.046Flagellar hook-associated protein flgK
    PA1454fleN−2.00.021Flagellar synthesis regulator FleN
Others
    PA1432lasI−2.30.001Autoinducer synthesis protein LasI
    PA3477rhlR−1.60.021Transcriptional regulator RhlR
    PA3478rhlB−12.20.001Rhamnosyltransferase chain B
    PA3479rhlA−9.90.001Rhamnosyltransferase chain A
    PA3724lasB−2.60.045Elastase LasB