TABLE 4.

Most overrepresented transcription factor binding sites in the promoter regions of the differentially expressed genesa

OrganismTFBSZ-score
S. salivarius CREB1 5.84
Evi1 18.7
FOXI16.45
Foxq18.35
MEF2A5.53
NHLH1 5.23
RXR-VDR9.50
Sox56.47
SRY9.29
Salmonella serovar E2F1 7.33
    TyphimuriumFOXF25.55
Myf 4.24
NF-κB 7.10
NFKB1 5.90
REL 5.05
RELA 8.80
Staf 5.28
S. aureus Foxd37.56
Gfi9.463
HNF1A 9.38
Lhx3 6.921
Nkx2-511.97
NKX3-1 5.597
Prrx2 7.153
RORA 10.54
Sox58.026
TBP 7.152
Foxd37.56
P. aeruginosa Foxa29.56
Foxd310.2
FOXI110.3
Gfi10.3
MEF2A8.26
NF-κB 3.69
Nkx2-5 9.26
Pax4 24.3
REL 6.30
RXR-VDR7.58
Sox58.62
SRF 6.53
SRY9.07
  • a Transcription factor binding sites (TFBS) in bold were unique to that particular experimental condition. NF-κB and its subunits are underlined. A Z-score of greater than 5 is considered to be statistically significant. For P. aeruginosa, NF-κB was also included, since an alternative statistical test (Fisher's exact test) suggested a P value of 0.036.