TABLE 1.

Candida albicans-endothelial cell adhesion molecules

C. albicans adhesinMorphogenetic expressioneEndothelial ligand(s) (potential ligand)Reference
αMβ2 (Mac-1; also called CD11b/CD18)Y + PHaCD54, CD102, CD149, 32, 48, 82
αvβ3 (CD51/CD61)Y + HcPECAM-1 (CD31)70, 73
αvβ5Y + Hd?70, 73
Als1Y + Hc?24, 25, 72, 83
Als2Y + Ha?86
Als3HN-cadherin65, 83
Als4Y + Ha,d?86
Als5bY?72, 84
Als6bY?72, 84
Als7bY?84
Als9Y?85
N-linked mannosyl residuesAll formsMR58, 81
O-linked mannosyl residuesAll formsTLR-43, 59, 60, 74
PhospholipomannanAll formsTLR-242
β-MannosidesAll formsGalectin-341
  • a Temperature-dependent expression.

  • b These molecules may be antiadhesive. See the text for further details.

  • c Increased expression on hyphae compared to yeast form.

  • d Decreased expression on hyphae compared to yeast form.

  • e Y, expressed on the yeast form; PH, expressed on the pseudohyphal form; H, expressed on the hyphal form.