TABLE 5.

Protection of orally immunized animals against a challenge with alpha toxina

Immunogen and/or route of administrationDose of alpha toxin (LD50)No. of survivors/total no. of miceMean time (h) to symptoms ± standard error of the mean
Naïve20/44.5 ± 0.5
Oral
    GST-Cpa247-370 (3.6 μg)60/62.5 ± 0.5
    PY7960/62.0 ± 0.5
    HT25166/6
    HT251123/6
    HT26666/6
    HT266122/6
Nasal
    GST-Cpa247-370 (0.015 μg)60/62.5 ± 0.3
    PY7960/62.0 ± 0.5
    HT25166/6
    HT251126/6
    HT26666/6
    HT266125/6
  • a Animals immunized as described for the experiments shown in Fig. 2 but from a separate experiment.