TABLE 4.

In vivo neutralization of alpha toxin activity

Antiserum and/or route of administrationaNo. of mice/group showing no signs of toxicity at time postinjection
<5 h10 h18 h24 h
Naïve0
Oral
    PY790
    HT2514432
    HT266440
Nasal
    PY790
    HT2514422
    HT266440
  • a Serum (day 60) obtained from mice immunized as outlined in Fig. 2 was pooled, diluted 1/5, and mixed with alpha toxin (2 h at 37°C) corresponding to 2 LD50. The preadsorbed toxin mixture was injected (i.p.) into individual mice, and symptoms were monitored.