TABLE 1.

Amino acid sequences of mature Ag85A, Ag85B, and Ag85C of M. tuberculosisa

AntigenSequence
1100
Ag85AFSRPGLPVEY LQVPSPSMGR DIKVQFQSGG ANSPALYLLD GLRAQDDFSG WDINTPAFEW YDQSGLSVVM PVGGQSSFYS DWYQPACGKA GCQTYKWETF
Ag85BFSRPGLPVEY LQVPSPSMGR DIKVQFQSGG NNSPAVYLLD GLRAQDDYNG WDINTPAFEW YYQSGLSIVM PVGGQSSFYS DWYSPACGKA GCQTYKWETF
Ag85CFSRPGLPVEY LQVPSASMGR DIKVQFQGGG PH..AVYLLD GLRAQDDYNG WDINTPAFEE YYQSGLSVIM PVGGQSSFYT DWYQPSQSNG QNYTYKWETF
101200
Ag85ALTSELPGWLQ ANRHVKPTGS AVVGLSMAAS SALTLAIYHP QQFVYAGAMS GLLDPSQAMG PTLIGLAMGD AGGYKASDMW GPKEDPAWQR NDPLLNVGKL
Ag85BLTSELPQWLS ANRAVKPTGS AAIGLSMAGS SAMILAAYHP QQFIYAGSLS ALLDPSQGMG PSLIGLAMGD AGGYKAADMW GPSSDPAWER NDPTQQIPKL
Ag85CLTREMPAWLQ ANKGVSPTGN AAVGLSMSGG SALILAAYYP QQFPYAASLS GFLNPSEGWW PTLIGLAMND SGGYNANSMW GPSSDPAWKR NDPMVQIPRL
201296        
Ag85AIANNTRVWVY CGNGKPSDLG GNNLPAKFLE GFVRTSNIKF QDAYNAGGGH NGVFDFPDSG THSWEYWGAQ LNAMKPDLQR AL.GATPNTG PAPQGA
Ag85BVANNTRLWVY CGNGTPNELG GANIPAEFLE NFVRSSNLKF QDAYNAAGGH NAVFNFPPNG THSWEYWGAQ LNAMKGDLQS SL.GAG∼∼∼∼ ∼∼∼∼∼∼
Ag85CVANNTRIWVY CGNGTPSDLG GDNIPAKFLE GLTLRTNQTF RDTYAADGGR NGVFNFPPNG THSWPYWNEQ LVAMKADIQH VLNGATPPAA PAAPAA
  • a The three amino acids essential for enzymatic mycolyl transferase function are indicated in bold.