TABLE 2.

Incidence and severity of arthritis in mice infected with UAMS-1 and RN6390 regulatory mutantsa

Strain (no. of mice)GenotypeIncidence (%) of:Inflammation scoreComposite score
ArthritisAbscessErosion of articular cartilageErosion of cortical bone
UAMS-1 (28)Wild type96.3 ± 3.796.3 ± 3.792.6 ± 7.489.6 ± 6.42.39 ± 0.165.18 ± 0.27
UAMS-929 (30) sarA 63.5 ± 11.8b53.8 ± 17.4b49.7 ± 10.1b37.7 ± 16.4b1.40 ± 0.23b2.80 ± 0.47b
UAMS-155 (21) agr 66.8 ± 3.2b66.8 ± 3.2b66.8 ± 3.2b66.7 ± 3.21.81 ± 0.313.81 ± 0.61
UAMS-930 (21) sarA/agr 33.2 ± 3.2b24.1 ± 5.9b23.7 ± 3.7b18.7 ± 8.7b0.57 ± 0.20b1.24 ± 0.43b
UAMS-969 (10) sarA (pSARA)100.070.0100.0100.02.40 ± 0.275.10 ± 0.38
RN6390 (8)Wild type75.075.062.575.01.88 ± 0.484.00 ± 0.95
UAMS-957 (9) sarA 33.333.322.222.20.56 ± 0.29b1.33 ± 0.69b
  • a Results for UAMS-969, RN6390, and UAMS-957 are based on one experiment. Results for other groups are reported as the mean ± the standard error of the mean.

  • b Difference between the parent and the mutant that is statistically significant (P < 0.05).