TABLE 2.

Human monocyte genes that are pneumolysin dependent and differentially expressed in response to S. pneumoniaea

Function group and accession no.LocusGene nameMolecular functionChange in expression (fold) with exposure to:
D39 vs. mediumD39 vs. PLN
Antipathogen response
    T72877IL1RNInterleukin 1 receptor antagonist1.33.5
    AA446103LMAN1Lectin, mannose-binding, 1Chaperone; mannose-binding lectin2.43.3
    N63943LYZLysozyme (renal amyloidosis)Lysozyme; amyloid protein; lysine3.02.9
    AA521362CR2/CD21Complement component receptor 21.20.3
Cell adhesion
    T65118CTNNA1Catenin alpha 1Cadherin-associated protein16.014.2
    AA088861CDH17Cadherin 17Calcium-dependent cell adhesion2.02.1
Cell cycle control: AA448659CDC25BCell division cycle 25BProtein tyrosine phosphatase5.73.7
Cell death and apoptosis
    H44953CASP4Caspase 4Apoptosis-related Cys protease3.12.6
    W45688CASP6Caspase 6Apoptosis-related Cys protease3.22.2
Cell-to-cell signaling
    H62864SCYA4Small inducible cytokine A4 (MIP-1β)Protein kinase; chemokine5.94.9
    AA040170SCYA7Small inducible cytokine A7 (MCP3)Chemokine3.93.1
    AA102526IL8Interleukin 8Cytokine2.72.4
Lipid, fatty-acid, and sterol metabolism
    AA436163PTGESProstaglandin E synthaseAntimicrobial humoral response4.03.9
    AA464238PAFAH1B3Platelet-activating factor acetylhydrolaseLipid metabolism; neurogenesis0.90.4
Protein degradation: H94487CTSECathepsin EProteolysis and peptidolysis3.52.1
Protein folding
    R98019APCSAmyloid P component, serumAcute-phase response protein1.54.0
    AA676404PPICCyclophilin CPeptidylprolyl isomerase4.83.1
Protein translocation: AA682386OLR1Oxidized low-density lipoprotein receptor 1LDL receptor0.930.14
Signal transduction
    AA057204IL2RBInterleukin 2 receptor, betaSignal transduction2.25.2
    AA054754IL15RAInterleukin 15 receptor, alphaSignal transduction2.34.5
    AA485426IFNAR2Interferon (α, β, and ο) receptor 2Antiviral response protein3.52.2
    AA431967TXNThioredoxinAntimicrobial humoral response2.32.1