TABLE 3.

ORFs within islands of S. flexneri 2457T categorized by function

Functional categoryNo. of ORFsSpecies with homologs
Virulence10 S. flexneri, Y. pestis
Adhesin7 S. enterica serovar Typhimurium, other pathogenic E. coli, A. actinomycetemcomitans
Regulatory5 E. coli O157:H7, S. enterica serovar Typhi, other pathogenic E. coli
Energy metabolism31other pathogenic E. coli, E. coli O157:H7, S. enterica serovar Typhimurium, C. crescentus, L. monocytogenes, S. enterica serovar Typhi
Iron uptake12 S. flexneri, S. boydii, S. enterica serovar Typhimurium, S. enterica serovar Typhi, other pathogenic E. coli
Resistance to organic or inorganic chemicals7other pathogenic E. coli, E. coli O157:H7, C. crescentus, M. loti, A. tumefaciens
Transport11 E. coli O157:H7, other pathogenic E. coli, S. enterica serovar Typhi
Membrane9 E. coli O157:H7, Y. pestis, K. pneumoniae, C. jejuni, S. enterica serovar Typhi
Plasmid replication and transfer functions7 C. crescentus, other pathogenic E. coli
DNA replication and transfer functions2 S. flexneri, S. enterica serovar Typhimurium
Cell structure9 E. coli O157:H7, other pathogenic E. coli, S. enterica serovar Typhi, S. enterica serovar Typhimurium
Biosynthesis8 E. coli O157:H7, other pathogenic E. coli
Central intermediary metabolism9 S. flexneri, V. cholerae
Conserved unknown68 S. flexneri, nonpathogenic E. coli, other pathogenic E. coli, S. enterica serovar Typhi, P. aeruginosa, X. fastidiosa, S. meliloti