Eosinophil numbers in control and reconstituted animalsa

Animal groupTotal no. of eosinophils (106)Mean cells per mouse ± SD
IL-4R−/− mice0.1, 0.12, 0.93, 0.65, 0.360.43 ± 0.36
SCID mice recipients of IL-4R−/− lymphocytes0.89, 2, 1.1, 1.3, 0.8, 0.7, 1.6, 1.6, 1.61.28 ± 0.45
  • a BALB/c SCID mice were reconstituted with total splenocytes from wt or IL-4R−/− donor animals prior to infection with B. malayi as in Fig. 5B. Total numbers of eosinophils were determined on the basis of their distinctive size and granularity profile as previously described (34, 40). Thus, T cells, even from IL-4R−/− mice, are able to reconstitute the ability of the recipient mice to recruit eosinophils to the peritoneal cavities in response to B. malayi infection.