TABLE 5.

Antibody responses of sera from vaccinees who were identified as carriers of meningococcia

Vaccinee no.Carrier isolateET-5 complementIgG bindingbSBA responses
P15 PorBP1.7,16 PorAP4 PorBP1.19,15 PorA
329B:15:P1.7,16++++Prevaccination ≥ postvaccination sera for all test strains
31715:P1.16++>4-fold for P15 antibodies
51415:P1.7+++>4-fold for P15 antibodies
56815:−+++>4-fold for P15 antibodies
4354:P1.15+++++>4-fold for P1.19, 15-1 antibodies
3314:P1.14+++
503NT:P1.15+++
384NT:P1.15+++≥4-fold for P1.19,15-1 antibodies
397NT:P1.15+>4-fold for P1.19,15-1 antibodies
314NT:−++
431NT:−++
469B:NT:−
474NT:−++
  • a Thirteen of the 40 vaccinees were carriers of meningococci at the time of the third vaccine dose. NT, nontypeable.

  • b Distinct binding of ≥1,000 arbitrary scan units to PorA and PorB on blots with OMV from H44/76 and CU385.