TABLE 1.

Results for rabbits given aerosol doses of different M. tuberculosis strains

Expt no.aStrainbMean impinger dose (CFU/ml) ± SDMean inhaled dose (CFU/ml) ± SELog10 inhaled bacilliMean no. of tubercles at 5 wkMean tubercle diameter (mm) ± SENo. of bacilli inhaled/tubercle
1H37Rv121,250 ± 16,530393,330 ± 63,1805.59278 ± 652.3 ± 0.11,415
2H37Rv31,170 ± 3,82060,050 ± 4,9504.7881 ± 211.6 ± 0.2741
3H37Rv105,000 ± 6,190410,000 ± 78,3005.61217 ± 531.6 ± 0.21,889
4H37Rv24,880 ± 2,49038,880 ± 6,2304.5865 ± 102.2 ± 0.2598
5aH37Rv7,930 ± 1,3403.908 ± 41.9 ± 0.2991
5bCDC15516008,500 ± 1,7303.925.1 ± 1.51.2 ± 0.21,667
6CDC1551(f)14,100 ± 1,67053,600 ± 6,5704.733 ± 0.80.8 ± 0.117,867
7Erdman134,170 ± 16,700309,300 ± 46,4405.49374 ± 971.93 ± 0.1827
8aErdman12,170 ± 2,09075,000 ± 20,9804.87210 ± 441.5 ± 0.1357
8bErdman(f)329,440 ± 8,8701,231,670 ± 196,9406.09353 ± 601.7 ± 0.13,489
9Erdman29,670 ± 1,93063,700 ± 7,0504.8094 ± 191.5 ± 0.1678
10Erdman34,330 ± 9,42060,470 ± 20,5604.78189 ± 512.0 ± 0.4320
11Erdman(f)52,330 ± 13,310113,830 ± 32,6905.06135 ± 232.8 ± 0.3843
  • a The number of rabbits per experiment was six, except for experiment 6, which had 12. Experiments 1 to 5 have been described previously (3, 10).

  • b (f), frozen thawed inoculum. All others were grown to logarithmic phase in 7H9 Middlebrook broth.