Mice rendered genetically deficient in CD1d-restricted NKT cells exhibit a spectrum of susceptibility to infectious disease

FindingαGalCer enhances host resistance in +/+ miceαGalCer not tested
CD1d−/− or Jα281−/− mice have more-severe disease than do +/+ miceP. aeruginosa, C. neoformans, HSV, ECMV-DbB. burgdorferi, Plasmodium-infected erythrocytes,a L. major, RSVa
CD1d−/− or Jα281−/− mice have disease similar to +/+ miceM. tuberculosis, Plasmodium sporozoite, T. cruzic
CD1d−/− or Jα281−/− mice have less-severe disease than do +/+ miceCoxsackievirus B3,b RSVaS. choleraesuis, L. monocytogenes,d Plasmodium-infected erythrocytesa
  • a The phenotype depends on the mouse strain.

  • b A role for diverse CD1d-restricted T cells is suggested by the data.

  • c The phenotype depends upon virulence of pathogen.

  • d Only anti-CD1d antibody blockade was tested.