TABLE 5.

M. tuberculosis CFU numbers in various monkeys at necropsya

MonkeyCategoryGranulomabRight lower or middle lungcLeft upper lungcLeft hilar lymph nodecRight hilar lymph nodec
no. 1no. 2
72-00Active-chronic; advanced disease at necropsy6.2 × 1042.2 × 1062 × 1048.3 × 1038.4 × 1021.2 × 104
112-01Latent, then severe disease1.9 × 1072.8 × 1053.7 × 1044.4 × 105NDd4.4 × 106
152-00Active-chronic then resolving4.8 × 1030 (all others)2.6 × 103000
146-00Latent1.1 × 103ND0001.5 × 103
  • a Tissue was homogenized in saline, dilutions were plated on 7H10 plates, and plates were read after 21 to 28 days of incubation at 37°C with 5% CO2. Data for representative monkeys of each category are shown.

  • b CFU in entire granuloma; 1 and 2 refer two different granulomas.

  • c CFU per gram of tissue.

  • d ND, not done.