TABLE 1.

M. tuberculosis (H37Rv)-derived H-2Kd epitopes predicted by use of the SYFPEITHI algorithm

H37Rv proteinsaPutative H-2Kd-binding amino acid sequencebEpitope positionsComputed score for H-2Kd
Membrane proteins (no. of transmembrane domains)
    Rv0051 (9)IYRPGRDLV487-49523
    Rv0111 (10)PYRYIGQTL509-51723
    Rv0194 (9)LYTPIGELA894-90223
    Rv0219 (4)SYGSGPLHL11-1925
Secreted proteins
    Rv0288 (TB10.4), Rv3019c (TB10.3)GYAGTLQSL20-28, 20-2827
    Rv3804c (Ag85A)VYAGAMSGLc144-15225
Proteins with unknown localizations
    Rv0065RYPHSPRLI76-8424
    Rv0127WYAGRNREL22-3024
    Rv0140SYYSVTTDA79-8727
    Rv0161RYRGRASAL31-3926
    Rv0164RYASRMPVL11-1924
    Rv0393, Rv0397TYVTTPGSA350-358, 27-2525