TABLE 2.

Characteristics of lesions and lung tissue

Patient no.Specimen or siteaHistopathologic examinationBacteriologyGenotypic analysis of selected drug targetsbmRNA expression of:
LesionAirwayAFBCulturerpoBkatGinhApncAembBrpsLrrsgyrAIL-2IL-12IFN-γiNOS
1SputumNumerousM. tuberculosisWTWTWTWTWTWTNDcWT
LULCavity wall (caseous necrosis)OpenNumerousM. tuberculosisWTWTWTWTWTK43RNDWT1201905,400ND
LLLCavity wall (caseous necrosis)OpenNumerousND1002206,300ND
LLLGranuloma (fibrocaseous)ClosedScantyM. tuberculosisWTWTWTWTWTWTNDWT854155,000ND
LNGranuloma (nonnecrotic)ClosedNoneND803408,700ND
2SputumNumerousM. tuberculosisS531LWTC15TWTM306VK88RNDWT
RULCavity wall (caseous necrosis)OpenModerateM. tuberculosisS531LWTC15TWTM306VK88RNDD89N1072443,14946
RLLCavity wall (caseous necrosis)OpenNumerousM. tuberculosisS531LWTC15TWTM306VK88RNDD94G893451,630621
RLLCavity wall (caseous necrosis)OpenScantyM. tuberculosisS531LWTC15TWTM306VK88RNDD89N281361,46521
RMLSmall nodule (caseous)ClosedScantyM. tuberculosisS531LWTC15TWTM306VK88RNDWT322401,19690
RLLInfarction (coagulative necrosis)ClosedScantyM. tuberculosisS531LWTC15TWTM306VK88RNDWT13897,243135
3SputumNumerousM. tuberculosisS531LS315TWT173 (T del)M306VK43RWTD94G
LULCavity wall (caseous necrosis)OpenModerateM. tuberculosisS531LS315TWT173 (T del)M306VK43RWTD94G801997,536207
LLLCavity wall (caseous necrosis)OpenScantyM. tuberculosisS531LS315TWT173 (T del)M306VK43RWTD94G92290715119
LLLFibrotic nodule (liquefaction)OpenModerateM. tuberculosisS531LS315TWT173 (T del)M306VK43RG1484TD94G803881,142129
LULGranuloma (caseous necrosis)ClosedModerateM. tuberculosisS531LS315TWT173 (T del)M306VK43RWTD94G1754211,86138
LLLMiliary nodules (caseous)ClosedScantyM. tuberculosisS531LS315TWT173 (T del)M306VK43RWTD94G6478202181
LLLNormal lung tissueScantyM. tuberculosisS531LWTWT173 (T del)WTK43RWTND64138605274
4SputumNoneNegative
LULGranuloma (nonnecrotic)ClosedNoneNegative10119785796
LULGranuloma (noncaseous)ClosedScantyNegative3132891,201103
LLLNormal lung tissueNoneNegative78107362373
5SputumNoneNegative
LULCavity wall (no necrosis)OpenNoneNegative1684092,407102
LLLGranuloma (fibrotic)ClosedNoneNegative763252,06614
6SputumNoneNegative
LULCavity wall (no necrosis)OpenNoneNegative872341,666145
LULGranuloma (caseous)ClosedNoneNegative1593852,541115
LLLMiliary nodules (caseous)ClosedScantyNegative901521,321270
  • a LUL and RUL, Left and right upper lobe; LN, lymph node.

  • b WT, wild type; boldface indicates changes in drug resistance compared to that in other lung lesions.

  • c ND, not done.