TABLE 3.

Severity of inflammation in skeletal muscle from TISP NHPs inoculated with B. burgdorferi strain N40 by needle or by tick bite

NHP no.GroupMuscle examinedInflammationaProliferationb
099NeedleBiceps1+6.7 ± 1.0
Quadriceps2+
177Biceps1+4.2 ± 0.3
Quadriceps2-3+
199Biceps2+8.7 ± 1.3
Quadriceps2+
383Biceps1+4.1 ± 1.6
Quadriceps2+
154Tick biteBiceps0-1+2.2 ± 3.0
Quadriceps0-1+
192Biceps1+2.0 ± 1.4
Quadriceps0
211Biceps1+2.0 ± 2.1
Quadriceps0
242Biceps01.8 ± 0.6
Quadriceps1+
  • a Severity of inflammation was graded from 0 to 4+ on HE-stained slides, as determined by masked examiner (see Materials and Methods for details).

  • b Mean and SD sum area in 103 square micrometers per ×40 microscopic field, as determined by masked digital image analysis of Ki67-immunostained sections (different sections from the same block as that used for HE staining).