TABLE 2.

Inhibition of lung IL-18 levels by ETA

Dose of ETA (ng/mouse)aMean ± SEM of IL-18 (pg/ml) in indicated tissueb
LungcLiverSerum
0 (control)838.5 ± 59.81,480 ± 14055.3 ± 8.6
20683.2 ± 40.1*1,540 ± 12079.7 ± 7.3
200449.7 ± 40.7***1,780 ± 7063.7 ± 23.4
2,000286.1 ± 28.5***1,580 ± 6083.3 ± 18.2
  • a Groups of three to five mice were inoculated with the indicated doses of ETA. Control mice received vehicle.

  • b Lungs and liver were removed 24 h following inoculation, and IL-18 levels were measured in the homogenates. Blood was collected 24 h following inoculation, and serum was prepared.

  • c *, P < 0.05; **, P < 0.001 versus respective control by factorial ANOVA.