Comparison of experimental infection models and naturally occurring chancroid

ModelGender susceptibilitySite of infectionRoute of infectionDose (CFU)Reduced temp requiredDuration (wks)Final outcomeLymphadenopathyAntibody responseCutaneous responseProtection from second challenge
MacaqueMales onlyForeskinIntradermal107No3Wet ulcerYesYesPMNs; lymphocytes, plasma cells, macrophagesNR
TDRMNRaBackIntradermal104-105Yes2EscharNoYesPMNs, lymphocytes, plasma cellsYes
SwineNREarPuncture104 (EDD)No4Dry ulcerNoYesPMNs, T cells, macrophagesNo
HumanBothbArmPuncture1-100 (EDD)No2PustuleNoNoPMNs, T cells, macrophagesNo
Natural diseaseBothcGenital skin and mucosa; nongenital skinSexually transmittedUnknownNoWeeks to monthsWet ulcer10-50%Yes (late in ulcerative stage)PMNs, T cells, macrophagesNo
  • a NR, not reported.

  • b Higher pustule formation rate was seen in males than in females.

  • c Higher prevalence is seen in males than in females.