TABLE 3.

Virulence of wild type and iron transport mutants of S. flexneri in the mouse lung model

S. flexneri strainPrimary challengeNo. of survivors/total after back challenge with S. flexneri serotype 2a strain 2457T
Time of deathNo. of survivors/total
SA100 (wild type)All dead by day 90/5NDa
SM100 (Strr)All dead by day 40/5ND
SA240 (iucD)Last death on day 61/51/1
SM166 (sitA)Last death on day 54/54/4
None1/5
  • a ND, not done.