TABLE 4.

Immunization of mice with N. lactamica or N. meningitidis OMVs protects against challenge with diverse meningococcal strains of different clonal lineages

N. meningitidis challenge strainChallenge dose (CFU)VaccineaNo. of survivors (no. healthy)No. of survivors/ no. in group at 72 h
24 h52 h
K4546 × 105None000/5
NL OMVs5 (5)5 (5)5/5
NM OMVs5 (5)5 (5)5/5
6 × 108None000/5
NL OMVs000/5
NM OMVs4 (3)3 (3)3/5
BZ1982 × 106None3 (0)3 (3)3/5
NL OMVs5 (4)5 (5)5/5
NM OMVs5 (5)5 (5)5/5
2.7 × 107None000/5
NL OMVs4 (4)4 (4)4/5
NM OMVs2 (2)2 (2)2/5
FAM181.6 × 106None000/5
NL OMVs4 (4)4 (4)4/5
NM OMVs3 (3)3 (3)3/5
2.3 × 106None000/5
NL OMVs2 (2)2 (2)2/5
NM OMVs2 (2)2 (2)2/5
NZ 394/985.5 × 106None5 (1)1 (1)1/5
NL OMVs5 (3)5 (5)5/5
NM OMVs5 (2)5 (5)5/5
7.5 × 107None000/5
NL OMVs5 (3)4 (4)4/5
NM OMVs5 (5)5 (5)5/5
BZ101.6 × 106None000/5
NL OMVs5 (5)5 (5)5/5
NM OMVs5 (5)5 (5)5/5
2 × 107None000/5
NL OMVs3 (3)1 (1)1/5
NM OMVs1 (1)1 (1)1/5
  • a NL, N. lactamica; NM, N. meningitidis.