TABLE 7.

Protection of mice against serogroup B and C meningococcal challenge following immunization with N. lactamica OMVs or <43-kDa protein pool and Alhydrogel as the adjuvant

N. meningitidis challenge strainChallenge dose (CFU)VaccineNo. of survivors (no. healthy)No. of survivors/ no. in group at 72 h
24 h52 h
B16B61.3 × 106None1 (0)1 (1)1/5
OMVs5 (5)5 (5)5/5
<43-kDa pool5 (5)5 (5)5/5
1.6 × 108None000/5
OMVs3 (0)2 (2)2/5
<43-kDa pool2 (0)2 (2)2/5
MC581.0 × 107None1 (0)1 (1)1/5
OMVs4 (2)4 (4)4/5
<43-kDa pool5 (4)5 (5)5/5
1.5 × 108None000/5
OMVs2 (1)2 (2)2/5
<43-kDa pool000/5
L91-5435.1 × 106None000/5
OMVs4 (2)4 (4)4/5
<43-kDa pool5 (2)5 (5)5/5
2.4 × 108None000/5
OMVs3 (0)3 (3)3/5
<43-kDa pool5 (2)5 (5)5/5
GN4.0 × 106None1 (0)1 (1)1/5
OMVs5 (5)5 (5)5/5
<43-kDa pool5 (5)5 (5)5/5
1.0 × 108None1 (1)1 (1)1/5
OMVs5 (5)5 (5)5/5
<43-kDa pool5 (2)4 (4)4/5