TABLE 3.

Immunization of mice with N. lactamica whole cells or OMVs protects against intraperitoneal challenge with N. meningitidis K454a

VaccineNo. of survivors (no. healthy)No. of survivors/ no. in group at 72 h
24 h52 h
None000/5
Killed whole cells5 (0)5 (5)5/5
OMVs5 (0)5 (5)5/5
Purified LOS3 (0)00/5
  • a The challenge dose was 108 CFU of K454. Whole cells were prepared with Alhydrogel; OMVs and LOS were prepared in Freund's complete adjuvant (first immunization) or Freund's incomplete adjuvant (subsequent immunizations).