TABLE 2.

Characteristics of the unique PPS 23F-specific Fabs

DonorClone% IdentityaJLL3 (aa)bVH% IdentityaIsotypeJHH3 (aa)b
0023B11L698.2JK410VH3-6496.1IgG2JH614
0027F3L6100.0JK110VH3-6496.1IgG2JH614
0028E11L6100.0JK110VH3-6495.7IgG2JH614
0081F9A2395.8JK29VH3-2390.7IgG1JK46
0082E7A2396.1JK29VH3-2392.1IgG2JH46
0082F7L696.7JK47VH3-4893.5IgG2JH216
0083A2L695.3JK47VH3-4893.5IgA2JH215
0083C12A2395.4JK39VH3-2393.2IgG2JH16
0083D7A2396.5JK39VH3-2391.1IgG2JH66
0084A3L696.7JK47VH3-4891.7IgG2JH216
0084B12A2395.5JK29VH3-2394.3IgG2JH16
0084B7L593.7JK29VH4-492.1*IgG2JH513
0084D1L696.6JK47VH3-4893.2IgG2JH216
0142B6L698.2JK410VH3-2394.6IgG2JH413
0146G9L698.2JK410VH3-2394.3IgA1JH413
0147A2L697.1JK211VH3-3095.7IgG2JH411
0186G5A2396.5JK29VH3-790.1*IgG2JH48
023102L698.2JK111VH3-3095.3IgG2JH411
023115A296.9JK18VH4-5993.1IgA2JH57
023125L696.4JK111VH3-3095.3IgG2JH411
0251C6A2397.7JK19VH3-2395.6IgA2JH53
0251H10L697.9JK311VH3-3093.1IgG2JH415
0254E12A2393.8JK19VH3-2394.9IgA2JH53
0255D3L697.9JK311VH3-3088.2IgA1JH415
0257A6L697.5JK311VH3-3093.1IgA2JH415
0257F5A2397.6JK19VH3-2395.7IgA2JH53
027064A2395.8JK29VH3-2393.0*IgG2JH56
027242A2395.1JK29VH3-2389.6IgA2JH56
027304A2395.1JK29VH3-2389.6IgA1JH56
027343A2394.1JK29VH3-2384.9IgA2JH56
  • a Percent nucleotide identy over the entire V region compared to the corresponding germ line gene.

  • b The number of residues comprising the Vκ (L3) and VH (H3) CDR3 regions. Fabs that contain in-frame insertions in the VH region (two residues in CDR1 of 008.4B7, two residues in framework 1 in 018.6G5, and one residue in CDR2 of 027.064) that were not considered in calculating the percent homology are marked by an asterisk.