TABLE 4.

In vitro and in vivo phenotype analysis of S. pneumoniae ABC transporter mutant strains using CI valuesa

StrainCI (95% confidence interval) with various sample types
THYBloodi.p.i.n.
ΔSp00901.10 (0.24-2.0)0.39 (0.31-0.47)0.49 (0.37-0.61)0.43 (0.23-0.63)
ΔSp01490.95 (0.67-1.22)0.46 (0.37-0.57)0.067 (0.031-0.10)0.041 (0.021-0.10)
ΔSp06101.40 (1.02-1.77)0.71 (0.58-0.83)0.70 (0.53-0.86)0.64 (0.15-1.20)
ΔSp07501.06 (0.86-1.25)0.40 (0.20-0.60)0.17 (0.078-0.26)0.018 (0.002-0.032)
ΔSp08460.95 (0.67-1.22)1.25 (0.90-1.60)0.61 (0.22-1.00)0.54 (0.30-0.79)
ΔSp16900.97 (0.77-1.18)0.92 (0.56-1.27)0.89 (0.41-1.38)NDb
ΔSp17960.82 (0.59-1.04)0.78 (0.56-0.99)1.30 (0.93-1.71)ND
ΔSp18240.95 (0.25-1.65)0.66 (0.43-0.89)0.59 (0.34-0.84)0.33 (0.01-0.67)
ΔSp21081.05 (0.71-1.40)1.25 (0.92-1.57)0.39 (0.29-0.49)1.00 (0.36-1.64)
  • a For mouse experiments, n = 3 to 10.

  • b ND, not done.