TABLE 1.

Visible pathology observed in vaccinated and control cattled

GroupNo. of animals with VL/total no. of animalsaNo. of animals with VL in LN/total no. of animalsaMean no. of LN with VL (95% CI)bMedian LN score (range)cNo. of animals with VL in lungs/total no. of animalsMean no. of lobes with VL (95% CI)bMedian lung score (range)cMedian total score (range)c
Control10/109/102.6 (1.2, 3.9)7.5 (0-14)10/102.9 (1.6, 4.2)10.5 (5-35)19.5 (5-35)
BCG9/107/101.4 (0.6, 2.4)2.5 (0-9)7/101.2 (0.5, 1.9)*5 (0-10)6 (0-18)
BM6/106/101.5 (0.4, 2.6)3.5 (0-11)5/10*0.7 (0.1, 1.3)***2.5 (0-9)**7.5 (0-16)*
BA6/106/101.2 (0.2, 2.2)2 (0-12)4/10*0.6 (0, 1.2)***0 (0-7)***3 (0-17)**
  • a Fisher's exact test.

  • b ANOVA with Tukey-Kramer multiple comparison test.

  • c Kruskal-Wallis test with Dunn's multiple comparison test.

  • d Shown are results of pathological changes found at postmortem examination performed 14 weeks postchallenge. Lung, lymph node, and total pathology scores were established using the scoring system described by Vordermeier et al. (37), as modified by Lyashchenko et al. (20). LN, lymph node(s); VL, visible lesions; CI, confidence interval. Significance is shown as follows: *, P < 0.05; **, P < 0.01; ***, P < 0.001.