TABLE 3.

Recovery of C. trachomatis MoPn IFU from the lungs of mice following i.n. challenge

No. of mice/groupAntigenAdjuvantImmunizationWt of lungs (g)aNo. of IFU recovered from lungs (106)a
RouteNo. of times
13MOMPCpG + alumi.m. + s.c.10.24 ± 0.02b2.3 ± 1.5c
14OvalbuminCpG + alumi.m. + s.c.10.30 ± 0.0243.2 ± 17.9
9C. trachomatis MoPni.n.10.23 ± 0.01b<0.00005c
13MOMPCpG + alumi.m. + s.c.30.23 ± 0.02b0.8 ± 0.3c
13OvalbuminCpG + alumi.m. + s.c.30.38 ± 0.01241.8 ± 90.8
11C. trachomatis MoPni.n.10.26 ± 0.01b0.001 ± 0.0001c
  • a The values are means ± standard errors.

  • b P < 0.05 as determined by the Student t test for the comparison with the corresponding ovalbumin-immunized group.

  • c P < 0.05 as determined by the Mann-Whitney U test for the comparison with the corresponding ovalbumin-immunized group.