TABLE 1.

Comparison of LD50 between intranasal and intravenous infections in wild-type mice and cytokine deficient mice

Mouse phenotypeaLD50 (CFU/mouse)b for:
Intranasal infectionIntravenous infection
Wild-type2 × 1085 × 105
IFN-γ−/−1.4 × 1037.2 × 102
TNF-α−/−7.2 × 1026.2 × 101
  • a Mice were infected intranasally or intravenously with different doses of L. monocytogenes.

  • b Ten to twelve mice were infected at each dose of L. monocytogenes.