TABLE 2.

Antilisterial resistance to an intravenous challenge with L. monocytogenes in intranasally immunized mice

Immunization routeaLog bacteria (CFU/organ)b in:
LiverSpleenLung
None4.12 ± 0.255.12 ± 0.311.14 ± 0.40
Intravenous2.52 ± 0.49c1.15 ± 0.17c<1.0
Intranasal2.87 ± 0.59c2.36 ± 0.76c<1.0
  • a Mice were immunized with 5 × 104 CFU of L. monocytogenes. They were reinfected intravenously with 5 × 104 CFU of L. monocytogenes.

  • b The number of L. monocytogenes in the organs was determined 2 days after secondary infection. Each results represents the mean ± standard deviation for a group of four mice.

  • c Significantly difference from the value for nonimmunized group (P < 0.01).