TABLE 2.

Meningococcal serogroup C responses 1 month after meningococcal conjugate vaccinea

Group (vaccination)VaccineOAc+ ELISAOAc ELISAOAc+ avidity ELISArSBA
No. testedGMC (95% CI)No. testedGMC (95% CI)No. testedGMC (95% CI)No. testedGMT (95% CI)
1 (DT or Td, then MCC)Chiron MCC-CRM19914.8 (12.2-18.0)5412.10 (9.23-15.85)557.73 (5.63-10.62)62740 (454-1,207)
Wyeth MCC-CRM13423.8 (18.3-30.9)5417.33 (12.46-24.12)5210.56 (7.02-15.88)582,048 (1,367-3,067)
Baxter MCC-TT19810.7 (8.9-12.9)3617.39 (10.87-27.81)354.16 (2.37-7.29)311,400 (763-2,569)
2 (MCC, then DT or Td)Chiron MCC-CRM17514.7 (11.4-18.9)4620.07 (12.61-31.93)5010.10 (5.53-18.44)511,142 (655-1,990)
Wyeth MCC-CRM15723.7 (18.3-30.6)4919.66 (12.99-29.77)4813.28 (7.68-22.96)551,898 (1,089-3,311)
Baxter MCC-TT17829.1 (24.3-34.9)3251.56 (32.8-81.0)3815.39 (9.81-24.13)284,412 (3,003-6,482)
3 (MCC with DT or Td)Chiron MCC-CRM19612.1 (9.5-15.3)5516.13 (10.31-25.57)5310.87 (6.50-18.19)63877 (515-1,494)
Wyeth MCC-CRM16320.1 (15.7-25.6)4818.71 (12.54-27.90)4513.66 (8.74-21.35)561,638 (991-2,710)
Baxter MCC-TT19323.8 (19.3-29.4)4131.99 (23.05-44.41)437.88 (5.07-12.26)412,191 (1,342-3,577)
  • a Specific IgG GMCs were measured by OAc+ ELISA, by OAc ELISA, and by the high-avidity ELISA, and rSBA GMTs were measured against strain C11.