TABLE 2.

Serum antibody responses to PsaA in different mouse strains

StrainAntigenAmt (pmol)Antibody titercIgG1/IgG2a ratio
CBA/JaPsaA50NAd
PsaA-IL-1β501,697 (1,026)11.8
PsaA-IL-25012,548 (3,331)1.4
PsaA-IL-45017,152 (2,324)2.1
PsaA-Adj5019,989 (4,737)12.5
C3H/HeJaPsaA501,021 (759)9.5
PsaA-IL-1β501,294 (1,023)7.8
PsaA-IL-25014,316 (4,604)1.0
PsaA-IL-45032,763 (13,763)1.0
BALB/cbPsaA250<100NA
PsaA-IL-225010,545 (2,422)1.3
PsaA-IL-42506,745 (2,933)1.5
PsaA-Adj250123,578 (47,477)9.2
  • a Groups of six CBA/J mice or C3H/HeJ mice were inoculated i.p. with the indicated antigens on days 0 and 21 and bled on day 35.

  • b Groups of 9 or 10 BALB/c mice were inoculated i.p. with the indicated antigens on days 0 and 11 and bled on day 21.

  • c Total anti-PsaA immunoglobulin titers were measured by ELISA for individual sera. Standard errors of the mean are indicated in parentheses.

  • d NA, not applicable.