TABLE 1.

Numbers of immune cells within the lungs at 3 weeks postinfectiona

Cellular infiltrate (105)No. of immune cells (SEM)
Low doseHigh dose
Aerosoli.v.Aerosoli.v.
WTCCR2−/−WTCCR2−/−WTCCR2−/−WTCCR2−/−
Macrophages0.81 (0.06)0.28 (0.06)∗∗0.64 (0.10)0.36 (0.050)∗8.30 (1.02)1.71 (0.33)∗∗∗5.06 (0.50)0.7 (0.16)∗∗∗
Neutrophils1.57 (0.24)2.35 (0.29)0.65 (0.29)1.70 (0.45)1.55 (1.23)45.9 (8.0)∗∗2.16 (0.26)24.54 (7.15)∗∗∗
CD4 T cells6.01 (0.88)3.72 (0.62)∗5.04 (1.11)3.58 (0.66)21.0 (2.84)9.5 (2.81)∗30.42 (5.31)16.81 (0.53)∗∗∗
CD8 T cells3.84 (0.46)4.28 (0.28)3.25 (0.64)2.5 (0.36)11.8 (1.32)8.18 (1.88)16.46 (3.21)8.7 (0.53)∗∗∗
  • a Numbers of macrophages, neutrophils, CD4+ lymphocytes, and CD8+ lymphocytes are represented from low-dose aerosol infections, low-dose i.v. infections, and high-dose aerosol and i.v. infections. Each value represents the mean of three to four mice. ∗, P ≤ 0.05; ∗∗, P ≤ 0.005; ∗∗∗, P ≤ 0.001. WT, wild-type mice; CCR2−/−, CCR2−/− mice.