TABLE 2.

Alignment of part of the VicX sequence with its closest homologuesa

Identification or accession no.Position of Zn binding motif (nucleotide position)Sequence
AJ01205051-80RKPED.LDAI LVTHEHRDHI HGVGVLARKY
VicX49-78RKPED.LDAI LITHEHSDHI HGVGVLARKY
YycJ45-74RKLDD.VDGI FVTHEHSDHI KGLGVVARKY
AJ01205251-80RNIQD.LNGI LVTHEHIDHI KGLGVLARKY
BLA2_BACCE102-131KKFQKRVTDV IITHAHADRI GGIKTLKER
BLAB_BACFR85-114DSLHAKVTTF IPNHWHGDCI GGLGYLQRK
BLAB_SERMA82-111ERGY.KIKGS ISSHFHSDST GGIEWLNSR
ConsensusitHHDiGglrk
  • a Alignment of a part of the VicX sequence with its closest homologues from B. subtilis (YycJ), E. faecalis (AJ012050), and S. aureus (AJ012052) and with β-lactamase precursor proteins from Bacillus cereus (BLA2_BACCE), Bacteroides fragilis (BLAB_BACFR), and Serratia marcescens (BLAB_SERMA). The β-lactamase fingerprint (Prosite documentation) is shown in boldface type. The position of the zinc binding motif of a sequence is indicated by nucleotide position. Numbering refers to the database entry. A consensus sequence is derived from this motif alignment and is shown according to the following rules: capital letters, amino acids conserved in all seven proteins; lowercase letters, amino acids present in at least five protein sequences.