TABLE 1.

Spontaneous and induced cytokine secretion by spleen cells from BALB/c and C57BL/6 mice during the early (6 days) and late (8 weeks) stages of T. congolense infectiona

ConditionsMouse strainInfectedInfection stageMean secretion (pg/ml) ± SE
IFN-γIL-10IL-4IL-13MCP-1
SpontaneousBALB/cNo400 ± 4810 ± 26 ± 36 ± 3250 ± 56
YesEarly2,500 ± 236a200 ± 19a50 ± 10a30 ± 10a1,800 ± 168a
C57BL/6No200 ± 3315 ± 35 ± 35 ± 2100 ± 29
YesEarly850 ± 90a250 ± 35a15 ± 3a5 ± 2250 ± 50a
YesLate150 ± 21c50 ± 15ac25 ± 5ad10 ± 2ad2,400 ± 350ad
Concanavalin A inducedBALB/cNo7,500 ± 450e200 ± 16e50 ± 15e20 ± 5e300 ± 58
YesEarly9,000 ± 854ae540 ± 47ae600 ± 115ae120 ± 20ae2,200 ± 363a
C57BL/6No6,000 ± 514e75 ± 12e24 ± 510 ± 2e50 ± 18
YesEarly10,000 ± 964ae320 ± 30ae50 ± 15ae10 ± 2e250 ± 74a
YesLate500 ± 54bce250 ± 50ae300 ± 25ade50 ± 5ade3,410 ± 500ad
  • a Letters following values indicate statistical significance. a, significantly higher compared to noninfected animals; b significantly lower compared to noninfected animals; c significantly lower compared to the early stage of infection; d significantly higher compared to the early stage of infection; e significantly higher compared to spontaneous release in the same mouse strain.