TABLE 1.

Diseases associated with AMP production changes

ConditionChanges in AMPaReference(s)
Atopic dermatitis↓LL-37, HBD-2, and dermcidin22, 23, 47, 53
Atopic eczema↓HBD-2, HBD-3, and LL-3722, 23, 45, 47, 53
Thermal injuryLack of HBD-2 production 49
Rosacea↑LL-37 peptide form 73
Psoriasis↑LL-3721, 32, 47
Infectious diarrhea↓α-defensin 28
Crohn's disease↓HBD-2 mRNA 15
Diabetes type ISNPs in HBD-1;↓LL-37 26
Oral bacterial infection in morbus Kostmann↓LL-37,↓human neutrophil peptides 51
Chediak-Higashi syndrome↓AMP in neutrophil granules 17
HIV-1 infection riskDEFB1 polymorphism41, 62
Tuberculosis↓mBD-3 and mBD-4; progressive disease3, 54, 55, 57, 58
↑mBD-3 and HBD-2; latent infection
↑LL-37 and CAMP; progressive disease
  • a ↓, diminished production; ↑, augmented production.