TABLE 2.

ECD caused by complemented strains of C. albicans

StrainRelevant genotypeaECD (%)b
AS18 tec1::hisG/tec1::hisG pCaTEC1102 ± 22
CAI4-URA3 ura3::λimm434/ura3::λimm434 pARG4-URA389 ± 9
CADS5 cph1::hisG/cph1::hisG efg1::hisG/efg1::hisG (EFG1)120 ± 23
CAP1-3121+pCT29 pmt1::hisG/pmt1::hisG pCaPMT193 ± 18
CAN35 efg1::hisG/efg1::hisG (EFG1)102 ± 15
DAY44 rim101::ARG4/rim101::URA3 pRIM10187 ± 27
CAS11 phr1::hisG/phr1::hisG (PHR1)122 ± 22
CLJ5+pVEC-CaCLA4 cla4::hisG/cla4::hisG pVEC-CaCLA488 ± 29
VIC21 mds3::UAU1/mds3::URA3 pMDS3103 ± 7
AS1-pCaTPK2 tpk2::hisG/tpk2::hisG pCaTPK286 ± 18
  • a Auxotrophies were complemented in all mutants. All mutants formed normal hyphae on endothelial cells after 3 h of incubation.

  • b Measured by specific 51Cr release. Results are the averages ± standard deviations of two experiments and expressed as the percentage of ECD caused by strain SC5314. The average specific 51Cr release caused by strain SC5314 was 24% ± 10%.