TABLE 2.

Antibody titers following immunization with PpAMA1 FVO or PpAMA1 3D7

Immunogena and rabbitELISA titerb to:FVO/3D7 titer ratio
PpAMA1 FVOPpAMA1 3D7
PpAMA1 FVO
    8550643,25021,0602.05
    8550853,65024,2102.22
    8551188,55042,8502.07
    8551432,24017,4401.85
    8551636,40015,3602.37
        Geometric mean47,473.222,566.72.10
PpAMA1 3D7
    855076,33016,6700.38
    8550938,40083,6500.46
    8551018,39037,8500.49
    8551542,25078,4000.54
    8551726,77052,6500.51
        Geometric mean21,915.946,519.60.47
  • a Rabbits were immunized three times at 3-week intervals, each time intramuscularly with 50 μg of antigen emulsified in Montanide ISA720 (days 0, 21, and 42). Titers shown are from bleeds 2 weeks after the third immunization (day 56).

  • b ELISA titers presented measure total IgG to the indicated recombinant protein in arbitrary antibody units (see Materials and Methods).