TABLE 4.

P. multocida genes previously shown to respond to low iron levels in vitro (31) that were up-regulated during growth within infected chickens

GenePredicted functionExpression valuea
c1c2c3
aroA3-Phosphoshikimate 1-carboxyvinyltransferase0.030.841.15
cydDTransport ATP-binding protein−0.010.641.58
fecBIron(III) dicitrate-binding periplasmic protein−0.130.101.51
fnrFumarate (and nitrate) reduction regulatory protein−0.991.451.21
folBDihydroneopterin aldolase0.450.820.80
hugZ_1Heme utilization protein−0.250.962.11
hugZ_2Heme utilization protein−0.250.962.11
ilvMAcetolactate synthase small subunit0.140.801.71
lldDl-Lactate dehydrogenase−0.372.222.08
nagBGlucosamine-6-phosphate isomerase0.200.800.79
nrdBRibonucleoside diphosphate reductase, beta chain0.600.460.85
PM0298Unknown−0.300.600.96
PM0300Putative TonB-dependent receptor−0.220.681.14
PM0336Putative TonB-dependent receptor0.361.092.20
PM0424Unknown−0.90−0.040.91
PM0452Unknown−0.211.041.67
PM0741Hemoglobin receptor precursor0.081.021.20
PM0803Unknown−0.610.701.86
PM1171Unknown−0.490.041.03
PM1460Phosphoglycerate transport system activator protein1.261.231.29
PM1604Unknown0.24−0.091.10
PM1727Unknown2.290.21−0.46
pqqLZinc protease−0.240.732.00
talTransaldolase0.180.671.44
trpGAnthranilate synthase component II1.390.200.87
yfeBIron(III) dicitrate transport ATP-binding protein0.100.911.70
yfeCIron (chelated) ABC transporter0.020.351.07
yfeDIron (chelated) transporter, permease protein0.050.541.13
  • a Expression values are expressed as the log2 of (average experimental intensity/average control intensity). Therefore, identical experimental and control expression values would be 0.0.