TABLE 1.

Immune response to S. flexneri 2a lipopolysaccharide in the inpatient trial

Dose (CFU)Volunteer no.No. of ASC/ 106 cellsaPeak increase (fold)Excretion
IgAIgGIgMIgAIgGIgM
10450011.11.11.0No
1244351.01.20.9Nob
115501.01.11.0Nob
64013553.91.41.5Yes
98536332.91.61.2Yes
101102191.71.21.2Yes
111333422.21.41.1Yes
31791731333.81.31.1Yes
718660904.82.51.2Yes
1032101101.31.11.0Yes
4752353.11.41.4Yes
82771753404.01.61.0Yes
GMTc3011182.21.41.1
  • a Peak number of antibody-secreting cells (ASC) per 106 peripheral blood lymphocytes.

  • b PCR positive.

  • c GMT, geometric mean titer (determined for both doses).