TABLE 4.

Vaccine potential of the Y. pestis Kimberley53pcm mutant straina

VaccinationAntibody responsebSurvival after challenge withc:
StrainDose (CFU)Anti-F1 antigenAnti-V antigen103 LD50s105 LD50s
Kimberley53pcm1059,248 (2.0)93 (7.7)10/109/10
10615,274 (2.8)216 (10.7)9/910/10
EV7610529 (4.2)<10 (1)1/101/10
10628 (3.8)15 (2.2)4/103/10
107799 (5.9)27 (2.7)9/108/10
Control<10<100/100/10
  • a For experimental details see Table 3, footnote a.

  • b The values are geometric mean titers (GeoStDv).

  • c The values are number of mice that survived/number of mice tested.