TABLE 1.

Helicobacter-specific IgG in immunized and/or infected mice

TreatmentaOD of Helicobacter-specific IgGbIgG1/IgG2ac
Nonimmunized, infected204 ± 1771.58 ± 0.62
Immunized, infected1,354 ± 5110.85 ± 0.6
Immunized, noninfected1,200 ± 125NDd
  • a Mice were immunized with CpG and H. pylori lysate (immunized) or injected with PBS (nonimmunized) and challenged with H. pylori (infected) or PBS (noninfected). At 3 months after the challenge, sera were taken from the mice and tested for H. pylori-specific IgG1, IgG2a, or total IgG by ELISA.

  • b Mean optical density (OD) of specific IgG for at least 12 mice in each group.

  • c The IgG1/IgG2a ratio was calculated from the ODs of Helicobacter-specific IgG1 and IgG2a of 12 mice in each group.

  • d ND, not done.