TABLE 2.

Colonization and persistence of Y. pestis strains in mice organs

Day postinoculationMouseCFU/organa
Kimberley53pcmEV76Kimberley53
SpleenLiverLungsSpleenLiverLungsSpleenLiver
212 × 1031 × 103<23 × 1036 × 103<21 × 1071 × 107
2<2<2<21 × 1022 × 102<25 × 1061 × 107
3<2<2<2<2<2<26 × 1065 × 106
315 × 1053 × 104<2<2<2<2b
2<22 × 103<2<2<2<2
3<2<2<2<2<2<2
71<25 × 105<2<2<2<2
2<2<2<2<2<2<2
3<2<2<2<2<2<2
101<2<2<21 × 103<2<2
2<2<2<2<2<2<2
3<2<2<2<2<2<2
  • a OF1 mice were s.c. inoculated with 106 CFU of either Kimberley53pcm, EV76, or Kimberley53. Animals were sacrificed on days 2, 3, 7, 10, 17, and 29 postinoculation. On days 17 and 29 postinoculation the organs of most sacrificed animals did not contain bacterial counts; the only exception was one animal inoculated with the Kimberley53pcm strain, which on day 17 had a low bacterial count in the liver (300 CFU). The limit of detection was 2 CFU/organ.

  • b —, the mouse was dead on day 3.