TABLE 1.

Cellular composition of lungs during pneumonia

Strain and time point (h)Resultsa
No. of cells (104)Granulocytes (%)Macrophages (%)Lymphocytes (%)
S. pneumoniae
    24
        TLR4 mutant45.6 ± 6.231.1 ± 3.761.3 ± 3.77.6 ± 1.7
        WT46.2 ± 6.434.0 ± 4.957.3 ± 5.08.6 ± 1.1
K. pneumoniae
    6
        TLR4 mutant63.5 ± 8.730.2 ± 3.144.1 ± 3.125.6 ± 2.1b
        WT77.6 ± 5.437.2 ± 5.155.0 ± 5.87.8 ± 1.1
    24
        TLR4 mutant82.3 ± 11.142.5 ± 5.635.4 ± 4.822.1 ± 2.5b
        WT90.5 ± 13.741.6 ± 3.723.3 ± 3.335.1 ± 1.5
  • a Results of total leukocyte counts and differential counts (expressed as percentages) in lungs of TLR4 mutant and WT mice infected with S. pneumoniae or K. pneumoniae at 6 and/or 24 h after infection. Data represent means ± SEM for six mice per group at each time point.

  • b P < 0.05 versus WT results at the same time point.